রবিবার, ৩১ মার্চ, ২০১৩

Veterans fight changes to disability payments

In this March 24, 2013 photo, former Marine Corps Cpl. Marshall Archer, left, a veterans' liaison for the city of Portland, Maine, speaks to a man on a street in Portland. Veterans groups are rallying to fight any proposal to change disability payments as the federal government attempts to address its long-term debt problem. They say they've sacrificed already. (AP Photo/Robert F. Bukaty)

In this March 24, 2013 photo, former Marine Corps Cpl. Marshall Archer, left, a veterans' liaison for the city of Portland, Maine, speaks to a man on a street in Portland. Veterans groups are rallying to fight any proposal to change disability payments as the federal government attempts to address its long-term debt problem. They say they've sacrificed already. (AP Photo/Robert F. Bukaty)

In this March 24, 2013 photo, veterans' liaison Marshall Archer, a former Marine Corps corporal, poses for a photo in Portland, Maine. Veterans groups are rallying to fight any proposal to change disability payments as the federal government attempts to address its long-term debt problem. They say they've sacrificed already. (AP Photo/Robert F. Bukaty)

(AP) ? Veterans groups are rallying to fight any proposal to change disability payments as the federal government attempts to address its long-term debt problem. They say they've sacrificed already.

Government benefits are adjusted according to inflation, and President Barack Obama has endorsed using a slightly different measure of inflation to calculate Social Security benefits. Benefits would still grow but at a slower rate.

Advocates for the nation's 22 million veterans fear that the alternative inflation measure would also apply to disability payments to nearly 4 million veterans as well as pension payments for an additional 500,000 low-income veterans and surviving families.

"I think veterans have already paid their fair share to support this nation," said the American Legion's Louis Celli. "They've paid it in lower wages while serving, they've paid it through their wounds and sacrifices on the battlefield and they're paying it now as they try to recover from those wounds."

Economists generally agree that projected long-term debt increases stemming largely from the growth in federal health care programs pose a threat to the country's economic competitiveness. Addressing the threat means difficult decisions for lawmakers and pain for many constituents in the decades ahead.

But the veterans groups point out that their members bore the burden of a decade of war in Iraq and Afghanistan. In the past month, they've held news conferences on Capitol Hill and raised the issue in meetings with lawmakers and their staffs. They'll be closely watching the unveiling of the president's budget next month to see whether he continues to recommend the change.

Obama and others support changing the benefit calculations to a variation of the Consumer Price Index, a measure called "chained CPI." The conventional CPI measures changes in retail prices of a constant marketbasket of goods and services. Chained CPI considers changes in the quantity of goods purchased as well as the prices of those goods. If the price of steak goes up, for example, many consumers will buy more chicken, a cheaper alternative to steak, rather than buying less steak or going without meat.

Supporters argue that chained CPI is a truer indication of inflation because it measures changes in consumer behavior. It also tends to be less than the conventional CPI, which would impact how cost-of-living raises are computed.

Under the current inflation update, monthly disability and pension payments increased 1.7 percent this year. Under chained CPI, those payments would have increased 1.4 percent.

The Congressional Budget Office projects that moving to chained CPI would trim the deficit by nearly $340 billion over the next decade. About two-thirds of the deficit closing would come from less spending and the other third would come from additional revenue because of adjustments that tax brackets would undergo.

Isabel Sawhill, a senior fellow in economic studies at The Brookings Institution, a Washington-based think tank, said she understands why veterans, senior citizens and others have come out against the change, but she believes it's necessary.

"We are in an era where benefits are going to be reduced and revenues are going to rise. There's just no way around that. We're on an unsustainable fiscal course," Sawhill said. "Dealing with it is going to be painful, and the American public has not yet accepted that. As long as every group keeps saying, 'I need a carve-out, I need an exception,' this is not going to work."

Sawhill argued that making changes now will actually make it easier for veterans in the long run.

"The longer we wait to make these changes, the worse the hole we'll be in and the more draconian the cuts will have to be," she said.

That's not the way Sen. Bernie Sanders sees it. The chairman of the Senate Committee on Veterans' Affairs said he recently warned Obama that every veterans group he knows of has come out strongly against changing the benefit calculations for disability benefits and pensions by using chained CPI.

"I don't believe the American people want to see our budget balanced on the backs of disabled veterans. It's especially absurd for the White House, which has been quite generous in terms of funding for the VA," said Sanders, I-Vt. "Why they now want to do this, I just don't understand."

Sanders succeeded in getting the Senate to approve an amendment last week against changing how the cost-of-living increases are calculated, but the vote was largely symbolic. Lawmakers would still have a decision to make if moving to chained CPI were to be included as part of a bargain on taxes and spending.

Sanders' counterpart on the House side, Rep. Jeff Miller, R-Fla., the chairman of the House Committee on Veterans' Affairs, appears at least open to the idea of going to chained CPI.

"My first priority is ensuring that America's more than 20 million veterans receive the care and benefits they have earned, but with a national debt fast approaching $17 trillion, Washington's fiscal irresponsibility may threaten the very provision of veterans' benefits," Miller said. "Achieving a balanced budget and reducing our national debt will help us keep the promises America has made to those who have worn the uniform, and I am committed to working with Democrats and Republicans to do just that."

Marshall Archer, 30, a former Marine Corps corporal who served two stints in Iraq, has a unique perspective about the impact of slowing the growth of veterans' benefits. He collects disability payments to compensate him for damaged knees and shoulders as well as post-traumatic stress disorder. He also works as a veterans' liaison for the city of Portland, Maine, helping some 200 low-income veterans find housing.

Archer notes that on a personal level, the reduction in future disability payments would also be accompanied down the road by a smaller Social Security check when he retires. That means he would take a double hit to his income.

"We all volunteered to serve, so we all volunteered to sacrifice," he said. "I don't believe that you should ever ask those who have already volunteered to sacrifice to then sacrifice again."

That said, Archer indicated he would be willing to "chip in" if he believes that everyone is required to give as well.

He said he's more worried about the veterans he's trying to help find a place to sleep. About a third of his clients rely on VA pension payments averaging just over $1,000 a month. He said their VA pension allows them to pay rent, heat their home and buy groceries, but that's about it.

"This policy, if it ever went into effect, would actually place those already in poverty in even more poverty," Archer said.

The changes that would occur by using the slower inflation calculation seem modest at first. For a veteran with no dependents who has a 60 percent disability rating, the use of chained CPI this year would have lowered the veteran's monthly payments by $3 a month. Instead of getting $1,026 a month, the veteran would have received $1,023.

Raymond Kelly, legislative director for Veterans of Foreign Wars, acknowledged that veterans would see little change in their income during the first few years of the change. But even a $36 hit over the course of a year is "huge" for many of the disabled veterans living on the edge, he said.

The amount lost over time becomes more substantial as the years go by. Sanders said that a veteran with a 100 percent disability rating who begins getting payments at age 30 would see their annual payments trimmed by more than $2,300 a year when they turn 55.

.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-03-30-US-Budget-Battle-Veterans/id-05819c3ebd0c4cbf8ae5701f9cf62fc5

Skyfall Chicago Marathon 2012 texas rangers steve jobs meningitis bobby valentine bobby valentine

শুক্রবার, ২৯ মার্চ, ২০১৩

Son of pro wrestler Ric Flair found dead

CHARLOTTE, N.C. (AP) ? Authorities say the son of professional wrestler Ric Flair has been found dead in a North Carolina hotel room.

Charlotte-Mecklenburg police says officers were called to a hotel on the city's south side around 10:30 a.m. Friday. When they arrived, they found the body of 25-year-old Reid Fliehr, who also was a wrestler.

A statement from police says there are no signs of foul play, and that the cause of death will be determined by the medical examiner's office.

Flair's agent released a statement Friday describing Reid as "an incredible son, brother, friend, and professional wrestler."

Ric Flair's real name is Richard Morgan Flair. The peroxide-blond wrestled for some 40 years and also was known as The Nature Boy.

The 64-year-old won many pro wrestling titles including in the WWE.

Source: http://news.yahoo.com/son-pro-wrestler-ric-flair-found-dead-201734268.html

Heather Clem Con Edison LaGuardia Airport weather radar the weather channel national grid LIPA

Eventful 2.0 Gives Its 20M Users A Personalized List Of Everything Going On Nearby

Eventful FeatureIt's not going to win any beauty pageants, but Eventful's 2.0 could make sure you never get bored. It's racked up 20 million registered users and shows of 4 million events at a time, but with today's big relaunch Eventful gets personalized thanks to your Facebook, iTunes, Spotify, and Last.fm data. That lets it show you concerts you'll love, along with movie times, conferences, festivals and more.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/jf-jOXp4Kuc/

Mayim Bialik Rich Kids of Instagram felix hernandez julia child Ron Palillo Chad Johnson Twitter Helen Gurley Brown

বৃহস্পতিবার, ২৮ মার্চ, ২০১৩

Playdek Closes $3.8M Series A To Build A Digital Community Where Tabletop Gamers Can Feel At Home

playdekFresh from putting smiles on the faces of tabletop gaming geeks everywhere, with yesterday's news that it would be helping to bring Dungeons & Dragons to iOS devices later this year, mobile game publisher Playdek has closed a $3.8 million Series A funding round. The round was led by Qualcomm Ventures, with IDG Ventures and ff Venture Capital also participating.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/4XBqWpCoRrs/

michael buble michael buble Jenni Rivera Alive Facebook Down bo jackson bo jackson hanukkah

Mount Sinai leads global program using stem cells to accelerate cures for Alzheimer's disease

Mount Sinai leads global program using stem cells to accelerate cures for Alzheimer's disease [ Back to EurekAlert! ] Public release date: 27-Mar-2013
[ | E-mail | Share Share ]

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine

Collaboration with the New York Stem Cell Foundation will involve using skin samples and brain imaging to identify causes and cures

Sam Gandy, MD, PhD, of the Icahn School of Medicine at Mount Sinai is leading an international team of researchers working to reprogram skin cells into brain cells to gain a better understanding of Alzheimer's disease (AD). As part of the Consortium, Dr. Gandy is collaborating with Scott Noggle, PhD, the NYSCF Charles Evans Senior Research Fellow for Alzheimer's Disease and Director of the New York Stem Cell Foundation (NYSCF)'s laboratory in Manhattan.

Dr. Gandy heads the Stem Cell Research Consortium funded by the Cure Alzheimer's Fund (CAF). The Consortium consists of six institutions that plan to directly investigate, for the first time, brain cells in petri dishes from individual patients who have the common form of AD.

Dr. Gandy is working with Dr. Noggle's team to reprogram skin cells from AD patients into brain cells using stem-cell technology. The research team will obtain and monitor adult AD brain cells, providing not only a way to study the causes of the disease but also a system for discovering potentially effective drugs. The strategy has been nicknamed "the patient-specific disease in a dish" and enables studies on a time scale of minutes or hours, compared with mouse model testing, which routinely requires nine months to one year.

"This approach is one of our best shots at understanding common forms of Alzheimer's. Once defects are identified, we can use these same brain cells to screen for new drugs," said Dr. Gandy, Professor of Neurology and Psychiatry and Director of the Center for Cognitive Health at Mount Sinai. "This breakthrough technology will enable us to identify genetic and biochemical differences underlying the most common form of Alzheimer's disease."

In collaboration with Mary Sano, PhD, Professor of Psychiatry and Director of the Mount Sinai Alzheimer's Disease Research Center (ADRC), Dr. Gandy plans to select carefully characterized patients and healthy participants from the ADRC who will have skin biopsies and will also undergo brain scans to detect the amount of amyloid plaque, the hallmark of AD, present in the brain. Samples will also be collected from a skin cell bank at the National Institutes of Health. The scans will be used to confirm AD, the risk for developing AD, and whether a brain is amyloid-free.

Dr. Noggle will reprogram these skin cells into the various cell types that make up the brain, employing the NYSCF Global Stem Cell Array, a breakthrough automated robotic technology that produces standardized stem cell lines. Results are specific to the patient's genetic makeup, allowing researchers to uncover Alzheimer's-related changes at an individual level and to track changes that might otherwise go undiscovered.

"Having all the cell types together in the same dish enables us to mimic as closely as possible the normal and the diseased adult human brain," said Dr. Gandy. "In these mixed cultures, we will study the roughly three-dozen genes that have been linked to AD to see if any are dysfunctional in such a way as to cause one or more known features of the disease."

To encourage international collaboration in Alzheimer's treatment, consortium researchers will create a stem cell bank that can be accessed globally to accelerate drug screening worldwide. This collaboration is an example of NYSCF's commitment to work with global collaborators to advance research.

"We can, for the first time, test drugs across a large, diverse population of Alzheimer's patients, using only their cells. This stem cell resource will embolden scientific investigations and accelerate bench to beside delivery of new treatments," said Dr. Noggle. "We're incredibly excited to be working with Dr. Gandy and fellow collaborators to find a cure for Alzheimer's disease."

###

Other organizations involved in the Consortium are Hadassah University Medical Center, Harvard Medical School and Massachusetts General Hospital, Harvard University Stem Cell Institute, and The Rockefeller University, who is pursuing related research separately funded by CAF.

About The Mount Sinai Medical Center

The Mount Sinai Medical Center encompasses both The Mount Sinai Hospital and Icahn School of Medicine at Mount Sinai. Established in 1968, the Icahn School of Medicine is one of the leading medical schools in the United States, and is noted for innovation in education, biomedical research, clinical care delivery, and local and global community service. It has more than 3,400 faculty in 32 departments and 14 research institutes, and ranks among the top 20 medical schools both in National Institutes of Health (NIH) funding and by U.S. News & World Report.

The Mount Sinai Hospital, founded in 1852, is a 1,171-bed tertiary- and quaternary-care teaching facility and one of the nation's oldest, largest and most-respected voluntary hospitals. In 2012, U.S. News & World Report ranked The Mount Sinai Hospital 14th on its elite Honor Roll of the nation's top hospitals based on reputation, safety, and other patient-care factors. Mount Sinai is one of 12 integrated academic medical centers whose medical school ranks among the top 20 in NIH funding and by U.S. News & World Report and whose hospital is on the U.S. News & World Report Honor Roll. Nearly 60,000 people were treated at Mount Sinai as inpatients last year, and approximately 560,000 outpatient visits took place.

For more information, visit http://www.mountsinai.org/.

Find Mount Sinai on:

Facebook: http://www.facebook.com/mountsinainyc

Twitter @mountsinainyc

YouTube: http://www.youtube.com/mountsinainy

About The New York Stem Cell Foundation

The New York Stem Cell Foundation (NYSCF) is an independent research institute founded in 2005 to accelerate cures and better treatments for patients through stem cell research. NYSCF has over 40 researchers in its New York laboratory and is an acknowledged world leader in stem cell research and in developing pioneering stem cell technologies, including the NYSCF Global Stem Cell Array. Additionally, NYSCF supports another 60 researchers at other leading institutions worldwide through its Innovator Programs, including the NYSCF Druckenmiller Fellowships and the NYSCF-Robertson Investigator Awards. NYSCF focuses on translational research in a model designed to overcome the barriers that slow discovery and replaces silos with collaboration.

NYSCF researchers have achieved four major discoveries in the field, including: the discovery of a clinical cure to prevent transmission of maternal mitochondrial diseases in December 2012; the derivation of the first-ever patient specific embryonic stem cell line (#1 Medical Breakthrough of 2011 by Time magazine); the discovery of a new way to reprogram stem cells; and the creation of the first disease model from induced pluripotent stem cells (also named the #1 Medical Breakthrough by Time magazine in 2008). More information is available at http://www.nyscf.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Mount Sinai leads global program using stem cells to accelerate cures for Alzheimer's disease [ Back to EurekAlert! ] Public release date: 27-Mar-2013
[ | E-mail | Share Share ]

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine

Collaboration with the New York Stem Cell Foundation will involve using skin samples and brain imaging to identify causes and cures

Sam Gandy, MD, PhD, of the Icahn School of Medicine at Mount Sinai is leading an international team of researchers working to reprogram skin cells into brain cells to gain a better understanding of Alzheimer's disease (AD). As part of the Consortium, Dr. Gandy is collaborating with Scott Noggle, PhD, the NYSCF Charles Evans Senior Research Fellow for Alzheimer's Disease and Director of the New York Stem Cell Foundation (NYSCF)'s laboratory in Manhattan.

Dr. Gandy heads the Stem Cell Research Consortium funded by the Cure Alzheimer's Fund (CAF). The Consortium consists of six institutions that plan to directly investigate, for the first time, brain cells in petri dishes from individual patients who have the common form of AD.

Dr. Gandy is working with Dr. Noggle's team to reprogram skin cells from AD patients into brain cells using stem-cell technology. The research team will obtain and monitor adult AD brain cells, providing not only a way to study the causes of the disease but also a system for discovering potentially effective drugs. The strategy has been nicknamed "the patient-specific disease in a dish" and enables studies on a time scale of minutes or hours, compared with mouse model testing, which routinely requires nine months to one year.

"This approach is one of our best shots at understanding common forms of Alzheimer's. Once defects are identified, we can use these same brain cells to screen for new drugs," said Dr. Gandy, Professor of Neurology and Psychiatry and Director of the Center for Cognitive Health at Mount Sinai. "This breakthrough technology will enable us to identify genetic and biochemical differences underlying the most common form of Alzheimer's disease."

In collaboration with Mary Sano, PhD, Professor of Psychiatry and Director of the Mount Sinai Alzheimer's Disease Research Center (ADRC), Dr. Gandy plans to select carefully characterized patients and healthy participants from the ADRC who will have skin biopsies and will also undergo brain scans to detect the amount of amyloid plaque, the hallmark of AD, present in the brain. Samples will also be collected from a skin cell bank at the National Institutes of Health. The scans will be used to confirm AD, the risk for developing AD, and whether a brain is amyloid-free.

Dr. Noggle will reprogram these skin cells into the various cell types that make up the brain, employing the NYSCF Global Stem Cell Array, a breakthrough automated robotic technology that produces standardized stem cell lines. Results are specific to the patient's genetic makeup, allowing researchers to uncover Alzheimer's-related changes at an individual level and to track changes that might otherwise go undiscovered.

"Having all the cell types together in the same dish enables us to mimic as closely as possible the normal and the diseased adult human brain," said Dr. Gandy. "In these mixed cultures, we will study the roughly three-dozen genes that have been linked to AD to see if any are dysfunctional in such a way as to cause one or more known features of the disease."

To encourage international collaboration in Alzheimer's treatment, consortium researchers will create a stem cell bank that can be accessed globally to accelerate drug screening worldwide. This collaboration is an example of NYSCF's commitment to work with global collaborators to advance research.

"We can, for the first time, test drugs across a large, diverse population of Alzheimer's patients, using only their cells. This stem cell resource will embolden scientific investigations and accelerate bench to beside delivery of new treatments," said Dr. Noggle. "We're incredibly excited to be working with Dr. Gandy and fellow collaborators to find a cure for Alzheimer's disease."

###

Other organizations involved in the Consortium are Hadassah University Medical Center, Harvard Medical School and Massachusetts General Hospital, Harvard University Stem Cell Institute, and The Rockefeller University, who is pursuing related research separately funded by CAF.

About The Mount Sinai Medical Center

The Mount Sinai Medical Center encompasses both The Mount Sinai Hospital and Icahn School of Medicine at Mount Sinai. Established in 1968, the Icahn School of Medicine is one of the leading medical schools in the United States, and is noted for innovation in education, biomedical research, clinical care delivery, and local and global community service. It has more than 3,400 faculty in 32 departments and 14 research institutes, and ranks among the top 20 medical schools both in National Institutes of Health (NIH) funding and by U.S. News & World Report.

The Mount Sinai Hospital, founded in 1852, is a 1,171-bed tertiary- and quaternary-care teaching facility and one of the nation's oldest, largest and most-respected voluntary hospitals. In 2012, U.S. News & World Report ranked The Mount Sinai Hospital 14th on its elite Honor Roll of the nation's top hospitals based on reputation, safety, and other patient-care factors. Mount Sinai is one of 12 integrated academic medical centers whose medical school ranks among the top 20 in NIH funding and by U.S. News & World Report and whose hospital is on the U.S. News & World Report Honor Roll. Nearly 60,000 people were treated at Mount Sinai as inpatients last year, and approximately 560,000 outpatient visits took place.

For more information, visit http://www.mountsinai.org/.

Find Mount Sinai on:

Facebook: http://www.facebook.com/mountsinainyc

Twitter @mountsinainyc

YouTube: http://www.youtube.com/mountsinainy

About The New York Stem Cell Foundation

The New York Stem Cell Foundation (NYSCF) is an independent research institute founded in 2005 to accelerate cures and better treatments for patients through stem cell research. NYSCF has over 40 researchers in its New York laboratory and is an acknowledged world leader in stem cell research and in developing pioneering stem cell technologies, including the NYSCF Global Stem Cell Array. Additionally, NYSCF supports another 60 researchers at other leading institutions worldwide through its Innovator Programs, including the NYSCF Druckenmiller Fellowships and the NYSCF-Robertson Investigator Awards. NYSCF focuses on translational research in a model designed to overcome the barriers that slow discovery and replaces silos with collaboration.

NYSCF researchers have achieved four major discoveries in the field, including: the discovery of a clinical cure to prevent transmission of maternal mitochondrial diseases in December 2012; the derivation of the first-ever patient specific embryonic stem cell line (#1 Medical Breakthrough of 2011 by Time magazine); the discovery of a new way to reprogram stem cells; and the creation of the first disease model from induced pluripotent stem cells (also named the #1 Medical Breakthrough by Time magazine in 2008). More information is available at http://www.nyscf.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/tmsh-msl032713.php

Alvin Lee nicki minaj jamie lynn spears kevin hart Chavez Dead Hugo Chavez Dead Bonnie Franklin

New insights into the development of the heart

Wednesday, March 27, 2013

Viewed from the outside, our body looks completely symmetrical. However, most internal organs ? including the heart ? are formed asymmetrically. The right side of the heart is responsible for pulmonary circulation; the left side supplies the rest of the body. This asymmetry allows the heart to do its job effectively. In a study on zebrafish embryos, the researchers Dr. Justus Veerkamp and PD Dr. Salim Seyfried from the Max Delbr?ck Center for Molecular Medicine (MDC) Berlin-Buch have now shown how the left and right sides of the heart develop differently.

A protein called Nodal plays an important role in the development of asymmetry. In an early stage of heart development, Nodal is formed on the left side and triggers a multi-step signaling cascade that enables the cardiac progenitor cells on this side to migrate faster. The researchers were able to observe the migration of the cardiac progenitor cells in the zebrafish embryos in vivo. Since the embryos are transparent it is possible to view each single cell using the microscope.

While analyzing the individual proteins involved in the asymmetric development of the heart, Dr. Veerkamp and Dr. Seyfried encountered a surprise: Previously, scientists had assumed that another signaling molecule, the protein Bmp, triggered cell migration on the left side of the heart and, as a consequence, must be very active there.

Current studies, however, show just the opposite: Bmp reduces the motility of the cells that form the heart. The protein Nodal regulates this process by activating the enzyme Has2. This in turn restricts Bmp activity on the left side. Thus, the cells of the left side of the heart migrate faster and ultimately form a functional, asymmetric heart.

However, when the researchers modulated the experiments so that individual proteins of the signaling cascade were expressed at elevated or decreased levels, the cardiac cells showed subtle differences in "random walk" cell motility rates. This resulted in the development of hearts that were completely symmetrical or whose sides were laterally inverted.

Many of these malformations of the heart in zebrafish embryos are also known in humans. Often asymmetric disorders not only affect the heart but also other organs such as the spleen. It may be missing or two spleens may be present. Depending on the severity of the malformations, the problems of the affected individuals vary in seriousness. It is also possible that the processes identified by the researchers are also involved in the development of diseases in which cell migration plays a role.

###

Their findings were published in the journal Developmental Cell (doi: http://dx.doi.org/10.1016/j.devcel.2013.01.026)

Helmholtz Association of German Research Centres: http://www.helmholtz.de/en/index.html

Thanks to Helmholtz Association of German Research Centres for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 35 time(s).

Source: http://www.labspaces.net/127475/New_insights_into_the_development_of_the_heart

northern lights sign of the times keystone pipeline purim acc tournament big ten tournament big east tournament 2012

Gmail's Priority Inbox Is Awesome. Just Give It a Chance

Gmail's Priority Inbox Is Awesome. Just Give It a ChancePriority Inbox is one of Gmail's best unsung features. It's amazing at curing email overload, but if you don't give it a chance to learn, all it'll do is muck up your inbox. Here's how to get it working properly.

Why Priority Inbox Is Great

If you're anything like me, you get a ton of emails a day, and sifting through them?let alone getting notifications for them?is a nightmare. Forget your previous experience with Priority Inbox for a second and assume it can actually read your mind. Your inbox is split up into multiple categories, so you see the important stuff right up top, out of the way of the junk. You don't have to scan your inbox at all to find it; it's just right there.

Furthermore, with Priority Inbox turned on, Gmail will only notify you when you have an important message. If you keep Gmail open in a tab, that unread count only goes up if you get an important email, so you aren't constantly tempted by an overflowing inbox. And, if you use Gmail for Android, you only get push notifications when something important comes through, so your phone isn't buzzing all day. Some would argue you should turn off email notifications entirely, but if you're only getting a few notifications a day from the people you want to hear from, notifications get a lot more enticing.

Okay, so you think that sounds good, but priority inbox has done nothing but let you down in the past. Chances are, you just need to help it learn a little bit more before it starts working. Here are a few ways to speed that process along.

First: Go About Your Email As Normal

Priority Inbox learns, first and foremost, just by watching you. If you frequently read messages from a specific sender, it learns to mark those as important, and if you frequently reply to emails from them, it knows even better. If you delete stuff without reading it, it'll learn that those aren't important. So, the last thing you should do is just go about your email as normal. Give Priority Inbox a bit of time to learn from your actions, and give it a little push when it needs it using the above tips. If you have just a little bit of patience, you should soon find that it's amazing at filtering your email for you, without a lot of extra work.

Use Filters and Labels

Gmail's Priority Inbox Is Awesome. Just Give It a ChanceFilters are an amazing tool, and they help Priority Inbox learn really fast. Say you want to mark emails from your coworkers as important. Just create a Gmail filter that matches from:lifehacker.com (or your company's email domain) and check the box that says "Always Mark As Important." Similarly, you can use any filter to never mark messages as important.

Labels work well for this, too. For example, I have a filter that applies a label called "Internal" to emails coming from any of my coworkers. Gmail now recognizes that many Internal emails are important, though it doesn't always mark them as important. Depending on the sender and the context of the message, it will use the Internal label as one more deciding factor, which is really handy.

Actively Mark Messages As Important (or Not Important)

Gmail's Priority Inbox Is Awesome. Just Give It a ChanceBefore it has time to watch your behavior, Gmail does a lot of guesswork when marking messages as important. Just like with its Spam button, it only takes a click to change a message's importance. If Gmail gets it wrong, just click the little yellow tag to toggle that message's importance. You can also use the + and - keys on your keyboard if you're a keyboard shortcut fanatic!

Don't get discouraged at the beginning. Again, the more you read your email, the more it'll learn?after a little bit of time, you'll rarely have to manually mark messages as important or unimportant again. You'll only need this at the beginning. Gmail actually updated Priority Inbox back in 2010 to give this more weight, so it should work better than it did at launch, too.

See Why Emails Are Marked as Important

Gmail's Priority Inbox Is Awesome. Just Give It a ChanceLastly, if you're ever confused as to why Gmail's marked a message as important, just hover your mouse over that little yellow tag and it'll tell you! Usually it's because of "the people in the conversation," because you "often read messages with this label," or something like that. Still, it can give you a little insight into what's going on inside Gmail's head, and what things you might need to do to correct it (for example, if you read emails with the "newsletter" tag but don't want to mark them as important, you'll need to create a filter that never marks newsletters as important).

Priority Inbox is my number one favorite Gmail feature, hands down. Without it, I'd spend a ton more time sifting through emails and checking my phone to see if anything important has happened at work. All it takes is a little patience to get working, but once you train it, it'll know important emails better than you do. Of course, if you decide you don't like it, it's easy to turn off, too.

Title image remixed from kanate (Shutterstock) and Mastepanov Pavel (Shutterstock).

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/DKzW4Dth3NA/gmails-priority-inbox-is-awesome-just-give-it-a-chance

Aurora Colorado Rajesh Khanna friday the 13th toy story 4 toy story 4 steam kristin chenoweth

সোমবার, ২৫ মার্চ, ২০১৩

10th Mountain trains to deploy with smartphone-compatible radios ...

10th Mountain soldiers train on a suite of new mobile equipment that allows them to maintain their communications network on the move and in combat.

FORT POLK, La. ? The U.S. Army is poised to send the first wave of soldiers to Afghanistan with a suite of new communications gear designed to boost mobile connectivity on the battlefield.

Some 1,600 soldiers with the 4th Brigade, 10th Mountain Division, will be the first to use the set of smartphone-compatible radios, networking systems and software in the combat zone. The troops are receiving accelerated training with the technology at Fort Polk, Louisiana, in preparation of their upcoming deployment, said Paul Mehney, a spokesman for the service.

Military?.com is traveling to the installation, located about 130 miles south of Shreveport, on March 24 to spend a day with the soldiers as they get acclimated to the new equipment, which includes products made by General Dynamics Corp. and Harris Corp.

?These guys are actually taking this stuff to go use it in Afghanistan,? Mehney said in an interview. ?This is their last stop prior to deployment.?

The mission comes as the White House is pressing for a faster withdrawal of U.S. forces from Afghanistan. President Barack Obama last month during his State of the Union address said the number of American troops in the country will be cut by half, to about 34,000, in a year. The war, he said, ?will be over? by late 2014. The question of how many troops will remain there is still a matter of debate.

In response to the evolving mission and budget uncertainty, the Army has decreased the number of brigades set to receive the communications gear to four brigades and two division headquarters ? down from eight brigades, Mehney said. The soldiers will be tasked with advising and assisting Afghan security forces rather than fighting insurgents, he said.

Sending troops to Afghanistan with the latest radios and networking equipment still makes sense because units will be losing access to fixed communications infrastructure, Mehney said.

?You?re not in a FOB anymore,? he said, referring to the military term for forward operating base, a protected position used to back combat operations. ?It?s a completely different mission. It?s a lot more mobile.?

The military has struggled for more than a decade to provide mobile connectivity to troops in austere environments. One of its capstone programs to deliver such a service, called the Joint Tactical Radio System, known as JTRS and pronounced ?jitters,? has been plagued with cost overruns, delays and malfunctioning prototypes.

The Defense Department in 2011 canceled the part of the system developing radios for tanks and trucks, known as Ground Mobile Radio and headed by Boeing Co. Last year, it downsized a similar effort for ships and other systems, known as Airborne and Maritime/Fixed Station and led by Lockheed Martin Corp., the world?s largest defense contractor.

However, the Pentagon last year also backed a piece of the system developing handheld and portable radios for troops, known as Handheld, Manpack and Small Form Fit and headed by General Dynamics. It authorized the Army to buy a total of more than 19,000 so-called Rifleman Radios from the company ? about 10 percent of the program?s planned quantity ? while holding a competition for the next phase of production.

Harris and Exelis Inc. are among the companies that plan to compete for the next round of production.

A separate Army program, called Nett Warrior, connects smartphones and tablets running Google Inc.?s Android software to the Rifleman Radio to transmit secure text messages and data.

Source: http://defensetech.org/2013/03/23/10th-mountain-trains-to-deploy-with-smartphone-compatible-radios/

cirque du freak paul pierce pope joan pope joan strikeforce tate vs rousey strawberry festival knicks

রবিবার, ২৪ মার্চ, ২০১৩

Arizona sends Harvard home with a thump, 74-51

SALT LAKE CITY (AP) ? Sometimes, it's rough being the smartest guy in the room.

Harvard freshman point guard Siyani Chambers knows.

He'll be heading back to Harvard missing part of his front tooth ? all part of a wicked basketball lesson provided by Arizona in a 74-51 crushing of the Crimson on Saturday in the NCAA tournament.

Mark Lyons matched a career high with 27 points to lead the sixth-seeded Wildcats (27-7), who showed how a real basketball school does it when March rolls around.

"The history of Arizona speaks for itself," coach Sean Miller said. "This time of year, we not only represent ourselves, but all the great players and teams of the past."

This will be Arizona's 15th appearance in the Sweet 16. The Wildcats are heading to Los Angeles for a West Regional matchup against Sunday's winner between Ohio State and Iowa State.

And Harvard ? well, it's back to class, though Chambers may want to stop by the dentist's office first.

"We got the rebound, we were on a fast break, I went in the air, came down, and before I knew it, my tooth was out," he said, in describing the inadvertent elbow he took early in the second half from Arizona guard Kevin Parrom.

Luckily, teammate Christian Webster was on the ball. He walked over to retrieve the tooth fragment and hand it back to its owner.

But there wasn't much to salvage by that point.

Harvard (20-10) missed its first 13 shots and 20 of its first 22 while falling behind 30-9. The Ivy League champs, who shot 52 percent in their upset win over New Mexico on Thursday, made only 27 percent in this one.

"We had some open opportunities early, and once we missed some, we kind of got our heads down and they took advantage of it," coach Tommy Amaker said.

Laurent Rivard, the Canadian guard who made five 3-pointers in the upset Thursday, shot 1-for-6 this time. He missed two early, then shot two airballs in the second half and finished with three points.

"They played me different than New Mexico did," Rivard said. "Stayed on me, forced us to finish inside. That changed the game."

Indeed, this was nothing like Thursday, when the upset over a physically imposing New Mexico team riled up the Harvard twitterrati and sparked dreams of nets somehow being cut down with a slide rule.

Yes, Amaker's program could be redefining what's possible in the Ivy League.

But Arizona, a team that hasn't lost to an opponent outside of the Pac-12 this season, had too much height, too much speed, too much talent to be slowed by this Harvard team.

"They pounced on us from the beginning," Webster said. "I think it took us by surprise how hard they played, how physical they were, their length and size and speed. From there, it was just an uphill battle."

Indeed, it was over early and a couple vignettes told the story.

Forward Solomon Hill (13 points, 10 rebounds) spotted up for a 3-pointer, drained it, then looped his fingers over his eyes ? the 3-point goggles ? right by the Harvard bench, in Amaker's face. On Harvard's next possession, Hill rebounded a missed shot, took the ball coast to coast and jammed with both hands, then bumped chests violently with Parrom.

Moments later, Lyons made a backdoor cut and took an alley-oop pass from Jordin Mayes for an easy layup.

Bad enough that happens to a defense once in a game. But on the next possession, Lyons and Mayes combined for an absolute carbon-copy of the same play.

"My teammates got me the ball in the right position and I was able to make shots today," said Lyons, a senior who came to Arizona from Xavier along with his coach.

Impressive as the back-to-back oops were, Chambers will remember another play better.

He was trying to make a jump pass, when Parrom left his feet, as well, to block it. His elbow bashed Chambers' lip and he grimaced in pain. Helped off the floor with the tooth in hand, he was wincing on the bench, where TV cameras caught a clear shot of his newly jagged right incisor.

"That showed how physical the game was," Rivard said. "It wasn't even close to the rim. Guys were scratching and clawing. But it was an accident."

Chambers came back shortly after and made a 3. He finished with six points.

Kenyatta Smith, Harvard's tallest player at 6-foot-8, led the Crimson with 10 points. Also shut down was Wesley Saunders. Saunders led Harvard with 18 points against New Mexico, but went 1-for-11 for eight points against Arizona.

"They're 7-feet, 6-9, 6-8," Amaker said. "They're in front of the rim, around the rim. They make it very difficult to finish."

Arizona, meanwhile, was every bit as good on offense as it was on defense. The Wildcats made 55 percent of their shots, led by Lyons' 12-for-17 night.

Source: http://news.yahoo.com/arizona-sends-harvard-home-thump-74-51-003031097--spt.html

bridge to nowhere primary results dale earnhardt jr michigan primary daytona 500 winner cleveland plain dealer john scott

Taliban threat forces Pakistan's Musharraf to cancel welcome rally

Kamran Jebreili / AP

Former Pakistani President Pervez Musharraf talks to a journalist in his office in Dubai, United Arab Emirates, before leaving for Karachi on Sunday.

By Waj S. Khan, Producer, NBC News

KARACHI, Pakistan - Pakistan's ex-president Pervez Musharraf who returned home Sunday after four years in self-exile, was forced to cancel a welcome rally after a video allegedly showing Taliban suicide bombers preparing to target the former leader was released.?

"The threat by the Taliban to General Musharraf's life is real, very real. There are increasing chances every hour that something could happen," said retired Maj. Gen. Rashid Qureshi, his former military spokesperson and now a member of Musharraf's political party, the All Pakistan Muslim League.

Musharraf had been expected to address supporters in Karachi, where he arrived from Dubai.

A video allegedly showing a squad of Pakistani Taliban suicide bombers being trained to target Musharraf was released on Saturday. Like threats in the past, they reiterated that they would kill Musharraf, who is blamed by Islamist militants for supporting the American "war on terror" in Afghanistan and Pakistan.

After landing in Karachi today afternoon, Musharraf was expected to briefly address a crowd, and will then be moved to an undisclosed location.

Photos:?Victims of Pakistan bomb attack mourned

His lawyer and party leader, Ahmad Raza Qasuri, said the former president will have a busy few days "dealing with the legal mess of three very serious cases that have been waiting for him."

On Friday his legal team won him no-arrest bail for three different cases ? one that charges him as a conspirator of the murder of former prime minister Benazir Bhutto in 2007, the killing of Akbar Bugti, a separatist politician, in 2006, and for forcibly detaining several judges in 2007 who wouldn't anoint his military rule.

The bail, according to Qasuri, was going to ensure that Musharraf was not arrested on arrival. The country's interior ministry had warned that Musharraf would be arrested as soon as he set foot in Pakistan.

According to the lawyer, Qasuri, Musharraf will have to travel to "unsavory?and unsafe places like Quetta [in Balochistan] to face the courts, which shows that he understands the risks of returning back here."

Related:

Malala Yousafzai, Pakistani teen shot by Taliban, back at school -- in UK

Pakistan captures suspect in death of journalist Daniel Pearl, officials say

Tough neighborhood: Can Waziristan militancy be dismantled, and society built?

Source: http://feeds.nbcnews.com/c/35002/f/653387/s/29ebe096/l/0Lworldnews0Bnbcnews0N0C0Inews0C20A130C0A30C240C174371160Etaliban0Ethreat0Eforces0Epakistans0Emusharraf0Eto0Ecancel0Ewelcome0Erally0Dlite/story01.htm

dick cheney heart umf elite eight stephon marbury the lion king suzanne collins cherry blossom festival

10 Fun Things You can Do with the Family during Earth Hour ...

Tomorrow, March 23, from 8:30 to 9:30 pm, the Philippines will once again take part in the great switch-off, Earth Hour 2013. And we Pinoys have every reason to be proud, because for the last four years that this global movement has been in practice, our country has been on top in terms of town and city participation.

(Related story: Philippines Aims for Earth Hour?s Top Spot for the 5th Year)

If you have ever participated in this endeavor, then you know just what turning off the lights for one hour equates to. In the past, the Philippines actually reduced energy consumption by as much as around 78 megawatts (about the power used by 780 car engines!) in Metro Manila alone.?

This year, whether you?re trying it out for the first time or adding another Earth Hour to your 2013 to-dos, turn it into an opportunity for some good ol? fun without the lights on. Here are some of our recommended activities that hopefully the whole family can enjoy.

shadow play

1. Play board games.
Earth Hour means just turning off the non-essential switches, so with a handy rechargeable lamp, you can still safely enjoy a game of Monopoly or Scrabble. Instead of each kid playing games on his smart phone, tablet or gaming console, this activity will let the family reconnect, the non-electronic way.

2. Make funny shapes with shadows.
Flash the light of your rechargeable lamp or flashlight onto a blank wall while you and the kids come up with funny or scary shadows. They?ll look like gigantic figures looming above you!

Source: http://www.smartparenting.com.ph/home-living/travel-trips-activities/10-fun-things-you-can-do-with-the-family-during-earth-hour

syracuse ohio state girl with the dragon tattoo ohio state basketball collateral dick cheney heart umf

Baby polar bears learn to crawl and walk (video) (Americablog)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/294012171?client_source=feed&format=rss

robin roberts Ashley Morrison El Chapo Guzman Christmas Abbott clive davis nba trade thomas robinson

শুক্রবার, ২২ মার্চ, ২০১৩

Wasp spiders move north explained

Temperature tolerance is key to the spread of wasp spiders into northern Europe, according to scientists.

Since the 1930s the distinctive spiders have expanded their range from the Mediterranean coast to Norway.

Researchers in Germany traced the population boom to breeding between the native European spiders and an isolated colony living near the Black Sea.

Molecular Ecology reports the genetic mixing resulted in generations rapidly adapting to living in colder climates.

Wasp spiders (Argiope bruennichi) are commonly named for their bright, striped abdomens and were recently recorded by the Woodland Trust in Usk, south Wales for the first time.

The first official records of this conspicuous species in the UK were made in the 1920s.

Henrik Krehenwinkel from the Max Planck Institute for Evolutionary Biology, Germany, analysed the DNA of spiders caught across their current range, and museum specimens to understand more about their evolutionary history.

Piecing together the genetic puzzle, he found that the spiders diverged after the last ice age: part of the population stayed on the Mediterranean while a colony headed east to Central Asia.

While these eastern populations adapted to live in climates as diverse as the tropical south of Japan and cold south-eastern Siberia, the spiders in the Mediterranean remained limited to warm areas.

But, according to the research, rising temperatures across the continent in the last century allowed the Mediterranean spiders to join up and breed with a previously isolated Black Sea population.

"This possibly restored genetic variation within a few generations and allowed for rapid adaptation," said Mr Krehenwinkel.

He theorised that the novel combination of genes resulted in new physical characteristics that helped spiders to survive in different environments.

Out in the cold

To test the whether these more northerly spiders adapted a different temperature tolerance than Mediterranean populations, the PhD student analysed how they reacted when moved into one another's habitats.

Southern spiders could not survive the freezing temperatures in the north, and their counterparts suffered from heat stress in the south.

Mr Krehenwinkel explained that the eastern population had adapted to cooler temperatures and this was passed on to European spiders in the population boom.

The result was the rapid adaptation of hardier offspring that could settle further north than their predecessors.

The spiders found in northern Europe have smaller bodies and are not seen in the coldest months of the year.

Scientists attribute both traits to seasonal changes which do not affect southern species. Spiders found in northern Europe "overwinter", meaning their young are buried during the coldest months; emerging in spring.

The spiders then have limited warm months in which they can mature, which restricts how large they can grow before they reproduce in the autumn and the cycle begins again.

Mr Krehenwinkel described the hatchlings as "highly dispersive", commenting that they can cover huge distances via a method known as "ballooning": riding the breeze on a special parachute made of gossamer silk threads.

"By aerial dispersal, little spiders can cover distances of several hundred kilometres," he told BBC Nature.

"Members of different genetic lineages can thus quickly track warming climate, which increases the likelihood of contact."

Join BBC Nature on Facebook and Twitter @BBCNature.

Source: http://www.bbc.co.uk/nature/21877948

kentucky jayhawks wwe wrestlemania oakland shooting mega millions winning numbers autism speaks ubaldo jimenez

Bookboard Launches App To Encourage Children To Read More By Limiting Their Choices

BookBoardHeroBrandedBookboard, a subscription service for children’s books, has launched its?iPad app, which gives parents and children streaming access to its library of books. Like many kids apps startups,?three former Adobe employees, Mike Fitzpatrick, Nigel Pegg, and Fang Chang, founded the company out of personal needs as parents. They came together to develop a service that encourages and develops a child?s love of reading. Bookboard?s library includes more than 300 books targeted at children ages 2-7. Parents can set up individual profiles for each child, track progress, and adjust the reading difficulty of books. According to Pegg, who is the CTO, the overarching goal for the company is ?What can Bookboard do to motivate kids to spend more time reading?? That ends up driving many of its design decisions, particularly incorporating game dynamics into the app. As kids get older and the system detects changing interests, the app adapts to the growing child. Bookboard?s secret sauce comes from its librarian Cen Campbell, who defines and applies library organization guidelines to the collection, including classifications, metadata, and reading level assessment. With metadata on hand, the system can tackle two big data problems: 1) unlock relevant “next books to read” and 2) apply collaborative filtering?techniques to recommend books. Unlocking Books – Incorporating Game Dynamics To Motivate A prevailing psychological theory, ?the tyranny of choice,? argues that when provided with too many choices, people feel overwhelmed and overloaded and are, as a result, unlikely to pursue any of the options available. In building out the product, the Bookboard team encountered their big aha moment when they discovered that progressive unlocking was the key to driving engagement of the service. In the beginning, the app presented the entire library to kids. The team noted that the ratio of time spent browsing titles to time spent reading was too high. Then the team introduced artificial scarcity into the initial set of books that kids could choose from. Kids are motivated to make it through books to see what will come next. The unlocking of more choices over time serves as a reward mechanism. As a result, the time spent reading, as opposed to browsing titles, is now the bulk of time spent within the app. When a book is earned via unlocking, it is read over 75 percent of the time. As kids progress in the app, they are presented with more book choices. Half of

Source: http://feedproxy.google.com/~r/Techcrunch/~3/iFfcct5LBn8/

egypt soccer riot facebook ipo facebook ipo mike kelley puxatony phil josh harvey clemons college football recruiting rankings

First message sent from space to be preserved by Library of Congress (video)

First message sent from space to be preserved by Library of Congress video

A 1958 message by then-President Dwight Eisenhower sent from space has been selected for National Recording Registry archives alongside 25 other notable recordings like Pink Floyd's The Dark Side of the Moon and, er, Chubby Checker's The Twist. Each audio recording was selected by the Library of Congress because of their cultural, artistic or historic importance to the United States however, the first message ever broadcasted from a space satellite was a short one. Eisenhower's 30-second speech included "America's wish for peace on Earth and goodwill toward men everywhere" and could be heard on shortwave radio as the satellite passed overhead. Project Signal Communications by Orbiting Relay Equipment (SCORE) was the world's first communications satellite and we've added a suitably old-school newsreel of its launch (and that slightly scrambled message) after the break.

Filed under: ,

Comments

Source: Space

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/aKNuDbeKraE/

mike wallace mike wallace Paul Bearer Cnn.com abc news brandi glanville Valerie Harper

মঙ্গলবার, ১৯ মার্চ, ২০১৩

Five Fab Wine Cellars - Connecticut Real Estate Blog

For a wine enthusiast entering the real estate market, a proper wine cellar is often on the list of important amenities that a new home should have. A wine cellar provides two key components that a bottle requires for good preservation and graceful aging: darkness and the perfect temperature. Over time, a fine vintage that is well stored will improve, releasing more complex aromas and flavors while also increasing in value. Here are a few properties now on the market that will undoubtedly appeal to wine lovers.

?

Stunning 1940 Estate, New Canaan, CT

After an afternoon exploring the 10+ acre grounds, featuring a beautiful sunlit hill and rolling green lawns sweeping down to a reservoir, this home invites guests to return for a relaxing evening of wine and entertainment. The five-bedroom, five full and two half-bath brick Colonial-style residence, constructed in 1940, includes a lovely wine cellar within its immaculately maintained, 5,443 square-foot interior.

?

A Magical Home for All Seasons, Darien, CT

This four-bedroom, four and a half-bath home enjoys a desirable country setting on its own peninsula with frontage on Gorham?s Pond, featuring an area to launch a kayak and peaceful views of the wildlife. Completing the picture of an ideal rural escape, the interior offers an inviting family room with a soaring stone fireplace, the perfect spot for settling down with a glass of red or white from the spacious wine cellar.

?

Your New Dream Home, Greenwich, CT

Located in the prestigious community of Conyers Farm, Ashfield Manor is a stately Colonial-style residence that truly embodies the concept of fine living. The 14,000 square feet of grand living space presents an atmosphere of timeless classic style, perfect for both casual living and distinguished entertaining. The property has an exquisite wine cellar for a superb collection, well suiting this elegant and distinctive home.

?

Baronial Stone Manor, Purchase, NY

The enormous wine cellar in this spectacular stone estate provides an excellent venue for sharing tastings with guests, offering a large center island beneath its curved ceiling. The other amenities offered on this luxurious property are no less amazing, including a 20? x 50? swimming pool and spa, 3,000 square-foot terrace overlooking the grounds and babbling brook, a sheer descent waterfall, and state-of-the-art systems.

?

Stunning Brick and Limestone Estate, Middlebury, CT

Every detail in this exceptionally crafted estate is carefully considered, from the entry foyer?s polished marble floors and Brazilian cherry hardwood and iron staircase to the tumbled travertine floor and custom carved cabinetry in the kitchen. The climate-controlled wine cellar is no exception, providing easy access from the adjacent dining room and offering the unique opportunity to enjoy private dining in true vintner fashion.

?

?

Source: http://blog.williampitt.com/2013/03/six-superb-wine-cellars/

the visitor king of kings ostara masters 2012 andy kaufman tom watson kawasaki disease

সোমবার, ১৮ মার্চ, ২০১৩

When The GOP Told Whitey I Aint Gonna Take It No More (talking-points-memo)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/291732573?client_source=feed&format=rss

rashad evans jon jones chuck colson death meteor showers 2012 ufc 145 jones vs evans marian hossa

The Patents I Never Filed?Multicast Networks ... - Business Insider

Anyone who follows me on Twitter or reads this blog knows I?m not a big fan of technology patents or patent law. I think they inhibit innovation and have become a weapon of small business destruction rather than a foundation of progress.

But that is not the point of this post.

Way back in the 1990s, Audionet/Broadcast.com was always having to invent new ways of streaming audio/video, presenting them to consumers and generating new revenue opportunities.

You know those pop up windows that Netflix has used for years? We created those. We called them ?Guaranteed Click Throughs? because we guaranteed that when a user clicked on them they would take you right to your website. We sold them for 25 cents EACH. That is how valuable traffic was back then.

Sure wish I patented them so I could prevent anyone else from ever using them!

There were some other things we were working on that I put together notes on. My lawyers wanted me to go through the entire process of patenting them. I just wanted to compete. So the patent applications never got past my note taking.

But in the interest of helping anyone who may ever face a patent troll on these topics, these are my notes. (And FWIW, I?m not saying these would definitely have gotten patents, and the in depth tech information is not in here. These were just notes to start a process that was never completed)

1. A Network of Multicast Networks

Invention Disclosure Form

Abstract (2-4 sentences): MultiNetworkMulticast Network ? A commercial network of multicast enabled networks. The composite of multiple Multcast enabled networks that terminates at a single point that enables digital content to be distributed in a one to many fashion across multiple networks from a single initiation point.?This enables providers of digital content to enable broadcast of those bits to an unlimited number of networks and hence, endpoints on that network of the content while only needing to enable a single source . ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Conception date (describe any available written evidence of conception):?Oct 1996

List all contributors to the project from which the invention arose:?Mark Cuban, Kevin Smith? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Has the invention been disclosed, or is it likely to be disclosed in the near future, to people or parties outside of the company? For example, has the invention been described, demonstrated or made available (i) to a vendor or customer; (ii) at a beta site; (iii) at a technical conference or trade show; (iv) or in a printed publication?? If so, provide the date and a description of each such disclosure and state whether the disclosure was subject to a non-disclosure agreement (NDA):?

Yes, the network is in use, and has been disclosed since Dec 1996

Identify each company project or product that utilizes or may utilize the invention.? Also list the current status of each such project or product, including any known or anticipated release, sales, shipping, beta testing, demonstration or public disclosure dates:

All streaming media and media distribution products used by the company benefits from this invention. The company has been working with commercial networks since 1996 to aggregate them into a single network. We have been building the network internally to link those networks, and have been testing the integration of application software to distribute those bits across multiple multicast enabled networks since January 1997.

We are currently actively working with Internet Service Providers and Network Backbone providers to integrate them into the process. Once integrated, the invention will allow us to distribute digital content in real time to a potentially unlimited size audience

Identify and describe any prior references that are relevant to the invention (e.g., known products, patents, publications, etc.):?

There exists a non profit network known as the Mbone. The mbone is a loosely coupled network of networks which can be joined or left at any point, without initiation or notice of departure. However, because it is not controlled or owned by any organization, there is no consistency for distribution on the network. There is no single point from which a content provider can go, link to? or integrate in order to assure the delivery of their digital content to all endpoints. We looked at this configuration and enhanced it by? creating defined links and destinations, creating the network of networks so that a content provider knows exactly what destination network endpoints are available, and the capabilities of those links??????????????????????????????????????????????????????????????????????????????????????? ??????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????? ???????????????????????????????????????????????????????????

State the problem that motivated or required the solution provided by your invention and briefly describe how your invention solves this problem:

In distributing digital content on the internet today, there is a huge problem of scale. Digital content is transmitted by sending a continuous stream of bits from an origination point, directly to a destination point in a 1 to 1 fashion. The problem is that number of destination points is limited by the amount of bandwidth available to the provider. So , to deliver 1gb of digital content to 100,000 users would require 100000000000000 bits of bandwidth!

The multicast protocol enables those same 1gb of content to be broadcast in a one to many fashion. However in order to receive those bits, users must be on a network that has been multicast enabled, and all the multicast networks that the desired audience exist on, must be linked to a common network. If the multicast enabled networks are not linked, then the content provider must originate content on each multicast enabled network separately.

By creating our network of networks, we enabled content providers to broadcast content one time to multiple multicast enabled networks. As a result, in the above example, only 1gb of bandwidth would be needed to reach those 100k users. ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Describe how others have tried to solve the same or similar types of problems, and describe how your invention differs from those solutions:

Others have tried to create organizations that encouraged people to work together to try to solve this problem, but it has not happened until we did it.

Strategic Importance: Briefly state why this invention is strategically valuable to the company.? In other words, explain (i) how it would benefit the company to be able to prevent one of our competitors from using this technology; or (ii) why the company would care if one of our competitors could prevent us from using this technology:

The company has spent considerable dollars and resources to enable this invention and offer the benefit to our customers.? We have contractually tried to protect ourselves. However, if a company were to copy our efforts, they could offer the same level of savings to digital content providers thereby injuring our profit potential and market position.

2. Personalization System ? 1998 ? This was a system we had designed and had implemented a simple version of, with the below enhancements in progress

The goal of this system is to find out as much as we possibly can about our users by asking them questions, track? exactly what they listen or watch and for how long, to allow them to create a My.Yahoo.Com? that lists their favorite content, with reminders for scheduled programs/events and recommendations for comparable content along with community items such as related newsgroups, chats, and the like.

It starts with a user going to a? webpage where they provide us demographics information, and then choose the categories of content they like. They also pick their favorite teams, artists, companies they follow? and schedules.

From there a custom Player SMIL file is created so that the user can have their personalization features presented to them inside the player. It will look like My.Yahoo, only in the player. A comparable HTML page will be created as well. So they can interact in either way

In addition to listings , there will be a calendar feature that can be local on the hard drive, or on a webpage , but it is personalized with games , shows, events based on the items chosen and reminders requested.? The user should also be able to go to a master calendar and drag and drop to the personal calendar

There also needs to be a personalized ticker with hot text ads, prices of selected stocks, and alarms or reminders of events chosen.

There should be a search feature in the player, that allows the user to search Broadcast.com for other items, whether live or on demand

There must then of course be personalized advertising. Based upon the demographics information provided and upon the content, audio and video that the user accesses. This of course means that we will need to keep multiple master databases of users,? their unique ID, the unique ID assigned by the media player. This will allow us to say that sample user, who has these characteristics, is now about to watch? this music video, so deliver this specified gateway ad , and during the content, deliver these following types of ads. The ads will be defined based upon category like zones. There needs to be an unlimited number of these categories for us to sell.

There must be a means of commerce. Commerce entails two levels, one is to buy? impulse merchandise associated with the content. So it could be a trip to Dallas when listening to the zone if the user is from out of town, or a free coupon to a restaurant if the user is in town, and of course if the user is listening to a CD from the jukebox, they must be able to buy the CD.? There must also be the option, in certain instances to save the audio or video to disk for a fee. This requires us to define the content as an object with characteristics that enabled depending on the geography (some content may only be available to local residents), or on whether we have the download rights,? or whether we have it available for sale as a product.

The goal is to offer personalization, track, suggest and sell.

We will sell products, ads, gateway ads, in content ads, and who knows what other types of digital opportunities that arise.

3. Self Service Hosting 1998 ? Broadcast.com Personal Broadcast Network

The goal is to allow a person to come to simplenet (Broadcast.com?s hosting subsidiary) and select a hosting option that allows them to offer on demand or live streaming content. To make a choice as to the size audience they would like to reach, and to have options as to how they would like to be promoted.

The system must also have a calendar component so that content can be included in a schedule if live, or as part of a search engine of on demand.? The content must also have the option of being private and having a password assigned that the user can hand out to whoever they want, and that will secure the stream.

The system must accommodate what happens on the back end server as well and of course the whole thing must happen WITHOUT any hands on intervention. Each service/offering must be hands free, completely self service so that it can scale. The only exception is for encoded of sent items, which will be charged on a per hour basis for handling.

  1. User Gets a Welcome to the Broadcast.com Personal Broadcast Network
  2. Please download Your Personal Broadcast Station. This is our custom? version of the real and netshow encoders combined in a single package. When you run it, it asks the following questions.

?Do you want to broadcast in Audio or Video?

  1. Live -

Ask them for a description of the show. Different questions for audio and video. Video, is it from a camera, VCR, is it music, talk only, news, lots of motion, little motion, sports, whatever we can think of . This helps us determine what kind of quality and encoder settings to suggest, and what speed PC is necessary to encode ?The assumption is that all feeds will be delivered via a dialup internet connection

  1. The user is asked if this is the PC that will deliver the live feed
    1. If yes, a tracer is done and the network they are using is determined. It is compared to a list of good and bad networks and an interpretation is made of the likelihood of good connections. ie, if its AOL, or if tracert is over 250ms, then a warning is issued.
    2. The software then? reads the hardware config, the cpu config, who the ISP is from the Wininet, and the speed of the connection and reads their modem configuration, and then sends it to us or allows them to upload the file it creates to us

A, If its video, what kind of video card they are using to capture (To determine compatibility of encoders)

1. If they don?t know, or don?t have a compatible card, they are offered a list of cards that we will sell them, with an option to have a local reseller install for an additional $99.95. In addition, they are offered a complete PC setup with all the required pieces ready to go for $2495 for video.

2. They are asked what the video source is, camera, vcr,

3. They are asked what kind of computer and configuration it is to make sure it has enough horse power to encode live video

B. If its audio, same kind of questions as above. Ask them if they will be using the mic that came with their computer. Ask them if they will be mixing multiple sources. Ask them if this is talk, news, sports, music, what level of quality they want.

C. Give them the option of buying multiple radio station setups. From software to program a music station, software only, or computer included, to devices to do remotes, devices to take phone calls, etc.

D. Promotional Options

  1. Be listed in the Broadcast.com Personal Broadcast Network Schedule ? $5 per month
  2. Have a featured time that appears in the whats on now homepage of the Personal Broadcast Network . Only one per scheduled time. Each time has a specific price, and once its taken, its gone. So Monday, 5pm is, lets say $60, Tuesday 2 a.m. is $5

Be listed in the Main Broadcast.com Live Events Listing $100 per month

4?????? Buy Banners on Broadcast.com

General Rotation $30 CPM, minimum of $100

Specific Location $50 CPM, minimum of $100

  1. Select the pricing option

On demand ? Per Month $ 29.95 for 14.4, 59.95 for 28.8., for up to 4 hours of content. Up to 50 simultaneous users. 25% discount if they run our gateway ads prior and use our SMIL template

Live ? 24?7

28.8 audio or video 19.95 up to 10 simul users, if they run gw

ads, 29.95 if not.

288 audio or video, 99.95 up to 25 simul users, 149 up to 50

if they run our gateway ads. Without gateway ads, $149 and ????????????????????????????????????????????????????????????? $199.

Option to save and make available as archive is priced same as o????????????????????????????????????????????????????????? on demand.

Final option (Till we think of more things), is the reporting option. It's another $10 for monthly reports, $30 for weekly reports.

On the backend, once a user completes the information and their credit card is approved, the backend software checks our server farm to find the next available server.This server has its config file modified to create a user block (this is already setup to work in real, not sure about netshow), and assign a password for the user, and an IP range based upon the tracert done from the software. This range (since its dialup its not a specific ip) limits the box the feed can come from . From there the user is emailed a server config file, along with an instruction manual on how to start the encoder and what directory to put the server config file. Then away they go!

If it's on demand, and they send encoded file, same thing happens. They encode the file and the destination is? our server. One difference is that we will set a disk quota based upon the number of hours and bit rate purchased. So if the user bought up to 4 hours of encoded 28.8 video, they get 25kbsx60x4 or 6mbs of disk storage.

The user is then sent complete instructions on how to link to the file. Or we can just license the RealNetworks publisher which has this built in.

Read more posts on Blog Maverick ?

Source: http://www.businessinsider.com/the-patents-i-never-filedmulticast-networks-personalized-streaming-and-advertising-and-self-service-hosting-2013-3

passover recipes 2012 kids choice awards kansas ohio state wrestlemania results womens final four josh hutcherson google april fools